Interleukin 4 signal transducers

Details Interleukin 4 signal transducers Interleukin 4 signal transducers

1994-07-15

1997-01-07

Ulm, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

536 231, 536 235, 435 691, 435 6, C12N 1512, C07K 1447

Patent

active

055918255

ABSTRACT:
The invention provides methods and compositions for identifying pharmacological agents useful in the diagnosis or treatment of disease associated with the expression of a gene modulated by an interleukin 4 signal transducer and activator of transcription, IL-4 Stat. IL-4 Stat peptides and IL-4 receptor peptides and nucleic acids encoding such peptides find therapeutic uses. The subject compositions include IL-4 Stat and IL-4 receptor proteins, portions thereof, nucleic acids encoding them, and specific antibodies. The disclosed pharmaceutical screening methods are particularly suited to high-throughput screening where one or more steps are performed by a computer controlled electromechanical robot comprising an axial rotatable arm.

REFERENCES:
Darnell Jr. et al., "Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins", Science 264:1415-1421 (1994).
Greenlund et al., "Ligand-induced IFN.gamma. Receptor Tyrosine Phosphorylation Couples the Receptor to its Signal Transduction System (p91)", The EMBO Journal 13(7):1591-1600 (1994).
Hou et al., "An Interleukin-4-induced Transcription Factor: IL-4 Stat", Science 265:1701-1706 (1994).
Kohler and Rieber, "Allergy-associated I.epsilon. and Fc.epsilon. Receptor II (CD23b) Genes Activated via Binding of an Interleukin-4-induced Transcription Factor to a Novel Responsive Element", Eur. J. Immunol. 23:3066-3071 (1993).
Kotanides and Reich, "Requirement of Tyrosine Phosphorylation for Rapid Activation of a DNA Binding Factor by IL-4", Science 262:1265-1267 (1993).
Paul and Seder, "Lymphocyte Responses and Cytokines", Cell 76:241-251 (1994).
Schindler et al., "STF--IL-4: A Novel IL-4-induced Signal Transducing Factor", The EMBO Journal 13(6):1350-1356 (1994).
Shuai et al., "Activation of Transcription by IFN-.gamma.: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein", Science 258:1808-1812 (1992).
Shuai et al., "Interferon Activation of the Transcription Factor Stat91 Involves Dimerization through SH2-Phosphotyrosyl Peptide Interactions", Cell 76:821-828 (1994).
Yin et al. (1994) J. Biol. Chem, vol. 269, pp. 26614-26617.

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