Benzoylguanidines, pharmaceutical composition containing them an

Details Benzoylguanidines, pharmaceutical composition containing them an Benzoylguanidines, pharmaceutical composition containing them an

1995-05-05

1997-01-07

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514603, 514618, 540231, 564 86, 564162, A61K 31165, A61K 31445, C07C31748, C07D21128

Patent

active

055917542

ABSTRACT:
Benzoylguanidines, process for their preparation, their use as a medicament and medicament containing them.
The invention relates to benzoylguanidines of the formula I ##STR1## where R(1) or R(2) is R(3)-S(O).sub.n -- or R(4)R(5)N--O.sub.2 S-- and the other substituent R(1) or R(2) in each case is H, OH, F, Cl, Br, I, alkyl, alkoxy, benzyloxy or phenoxy, R(3)-S(O).sub.n or R(4)R(5)N-- or 3,4-dehydropiperidine and R(3) is alkyl, cycloalkyl, cyclopentylmethyl, cyclohexylmethyl or phenyl, R(4) and R(5) are alkyl or phenylalkyl or phenyl,

REFERENCES:
patent: 3780027 (1973-12-01), Cragoe, Jr. et al.
patent: 5091394 (1992-02-01), Englert et al.
patent: 5292755 (1994-03-01), Englert et al.
Schmid et al., "Na.sup.+ /H.sup.+ Exchange In Porcine Cerebral Capillary Endothelial Cells Is Inhibited By a Benzoylguanidine Derivative", Biochem. and Biophys. Research Communications, 184(1):112-117 (1992).

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