Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-08-15
1997-01-07
Fleisher, Mindy
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514832, 530385, 530402, 530409, 530410, 530829, A61K 3514, A61K 3816, C07K 14805
Patent
active
055917100
ABSTRACT:
Compositions and processes to alleviate oxygen toxicity are disclosed based on the addition of nitroxides to physiologically compatible macromolecules. In particular, hemoglobin-based red cell substitutes are described featuring stable nitroxide free radicals for use in cell-free hemoglobin solutions, encapsulated hemoglobin solutions, stabilized hemoglobin solutions, polymerized hemoglobin solutions, conjugated hemoglobin solutions, nitroxide-labelled albumin, and nitroxide-labelled immunoglobulin. The formulations described herein interact with free radicals, act as antioxidant enzyme-mimics, and alleviate oxidative stress and oxygen-related toxicity.
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Degen Nancy J.
Fleisher Mindy
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