Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-08-28
1998-12-08
Myers, Carla J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4353201, 536 235, 530350, 530827, 935 9, 935 11, C12N 1500, C07K 14435, C07H 2104
Patent
active
058467785
ABSTRACT:
The present invention provides nucleic acid and amino acid sequences that identify and encode a novel human map kinase homolog (SMAP) expressed in cells of the human stomach. The present invention also provides for PCR oligomers or hybridization probes for the detection of nucleotide sequences encoding SMAP or SMAP-like molecules, antisense molecules to the nucleotide sequences which encode SMAP, diagnostic tests based on SMAP encoding nucleic acid molecules, genetically engineered expression vectors and host cells for the production of purified SMAP, antibodies capable of binding specifically to SMAP, and agonists and inhibitors with specific binding activity for the polypeptide SMAP.
REFERENCES:
Davis, RJ, "MAPKs: new JNK expands the group" TIBS 19:470-473 (1994).
Derijard, et al., "Independent Human MAP Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms" Science 267:682-686 (1995).
Egan, SE and Weinberg, RA, "The pathway to signal achievement" Nature 365:781-783 (1993).
Han et al., "A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells" Science 265:808-811 (1994).
Lee et al., "A protein kinase involved in the regulation of inflammatory cytokine biosynthesis" Nature 372:739-745 (1994).
Au-Young Janice
Guegler Karl J.
Hawkins Phillip R.
Wilde Craig G.
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Mohan-Peterson Sheela
Myers Carla J.
LandOfFree
Human map kinase homolog does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Human map kinase homolog, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Human map kinase homolog will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-176245