Chemical modification of elsamicin A at the 3' and/or 4' OH grou

Details Chemical modification of elsamicin A at the 3' and/or 4' OH grou Chemical modification of elsamicin A at the 3' and/or 4' OH grou

1992-11-10

1993-07-20

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 34, 536 168, 536 175, 536 172, 536 181, A61K 3171, C07H 1704

Patent

active

052293718

ABSTRACT:
This invention relates to novel elsamicin A derivatives having an alkylidene group on the 3' and 4'-OH group or a tetrahydropyranyl group on the 4'-OH group, a process for producing said elsamicin A derivatives, antitumor composition containing the same as the active ingredient, and a method for therapy using said compositions.

REFERENCES:
patent: 4518589 (1985-05-01), Konishi et al.
patent: 4760136 (1988-07-01), Mori et al.
patent: 4927919 (1990-05-01), Yamada et al.
patent: 5064945 (1991-11-01), Yamada et al.
patent: 5149793 (1992-09-01), Yamada et al.
McOmie, J. F. W., Protective Groups in Organic Chemistry, pp. 117-118, 1973.
Konishi, et al., J. Antibiotics, 39: 784-791, (1986).
Sugawara, et al., J. Org. Chem., 52: 996-10001, (1987).
Leach, et al., J. Am. Chem. Soc., 75: 4011-4012, (1953).
In progress in Medicinal Chemistry, Ed., G. P. Ellis & G. B. West 19; pp. 247-268, Elsevier Biomedical Press Amsterdam, (1982).
Simonitsch, et al., Uber die Struktur des Chartreusins I, Helv. Chim. Acta, 47: 1459-1475, (1964).
Eisenhuth, et al, Uber die Struktur des Chartreusins II, Helv. Chim. Acta, 47, 1475-1484, (1964).

Affiliated with

Also associated with

Rating

Chemical modification of elsamicin A at the 3' and/or 4' OH grou does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chemical modification of elsamicin A at the 3' and/or 4' OH grou, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chemical modification of elsamicin A at the 3' and/or 4' OH grou will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1760545