Cyclic hexapeptide compounds

Details Cyclic hexapeptide compounds Cyclic hexapeptide compounds

1991-02-19

1993-07-20

Chan, Y. Christina

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530317, 530323, 530332, A61K 3702, C07K 754

Patent

active

052293637

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or hydroxyl; R.sub.2 is hydrogen; hydroxyl or methyl, R.sub.3 is hydrogen or hydroxyl; R.sub.4 is C.sub.5 -C.sub.23 alkyl, C.sub.5 -C.sub.23 alkenyl, aryl or substituted aryl; R.sub.5 is --CH.sub.2 OH, --CH(CH.sub.3)OH, --CH(CH.sub.2 CONH.sub.2)OH; R.sub.6 is --CH.sub.2 OH or --CH(CH.sub.3)OH; R is --CH.sub.2 OH or --CH(CH.sub.3)OH; provided that when R.sub.4 is --(CH.sub.2).sub.8 CH(CH.sub.3)CH.sub.2 CH(CH.sub.3)C.sub.2 H.sub.5, R.sub.5 is --CH.sub.2 OH or --CH(CH.sub.3)OH. The compounds are useful as antimicrobial agents, especially as antifungal agents.

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Edman et al., Nature, vol. 334, pp. 519-522 (1988).
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N. Kurokawa et al, (2) J. Am. Chem. Soc. 108, 6043-6045 (1986).
M. Sakaitani et al, 30 2251-2254 (1989).

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