In-vitro method for producing antigen-specific human monoclonal

Details In-vitro method for producing antigen-specific human monoclonal In-vitro method for producing antigen-specific human monoclonal

1990-04-26

1993-07-20

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435 7021, 435 704, 43524027, 4352402, 530351, 5303871, 5303881, 424 852, C12P 2108, C12N 506, C07K 1526

Patent

active

052292754

ABSTRACT:
A method of amplifying production of IgG, IgA and IgM antigen specific human monoclonal antibodies from transformed, T-cell depleted, human peripheral blood lymphocytes through the use of an adjuvant system consisting of 8-mercaptoguanosine and at least one of the cytokines interleukin-4 and interleukin-6. Also included in the invention is the adjuvant system and a kit comprising the system.

REFERENCES:
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