Adoptive immunotherapy with interleukin-7

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4352402, 435 701, 424 852, 424534, A61K 3514, A61K 3702, C12N 508

Patent

active

052291154

ABSTRACT:
There is disclosed an immunotherapy method for treating an individual with cancer or a viral infection comprising obtaining lymphoid cells previously exposed to a specific antigen, culturing the lymphoid cells ex vivo in a culture medium containing an effective amount of an IL-7 polypeptide or a functional derivative thereof to induce CTL activity in the lymphoid cells and administering the lymphoid cells having CTL activity for cells displaying the specific antigen to an individual.

REFERENCES:
patent: 4902288 (1990-02-01), Ingram
patent: 4965195 (1990-10-01), Namen et al.
patent: 5032396 (1991-07-01), Williams
patent: 5041289 (1991-08-01), Philips et al.
Matis et al., J. Immunol. vol. 136(9), May 1986 pp. 3496-3501.
Rosenberg, S. A. Adoptive Immunotherapy for Cancer. Scientific American, pp. 62-69, May, 1990.
Parmiani, G. An Explanation of the Variable Clinical Response to Interleukin-2 and LAK Cells. Immunology Today 11:113, 1990.
Widmer, M. B. et al., Regulation of Cytolytic Cell Population from Human Peripheral Blood by B Cell Stimulatory Factor 1 (Interleukin-4). J. Exp. Med. 166: 1447; 1986.
Kawakami, Y. et al. Interleukin-4 Promotes the Growth of Tumor-Infiltrating Lymphocytes Cytotoxic for Human Autologous Melanoma. J. Exp. Med. 168: 2183; 1988.
Mule, J. J. et al. IL-4 Regulation of Murine Lymphokine-Activated Killer Activity In Vitro. J. Immunol. 142: 726; 1989.
Namen, A. E. et al. B Cell Precursor Growth-promoting Factor. J. Exp. Med. 167: 988; 1988.
Namen, A. E. et al. Stimulation of B-Cell Progenitors by Cloned Murine Interleukin-7. Nature 333: 571; 1988.
Cosman, D. et al. Interleukin-7: A Lymphoid Growth Factor Active on T and B Cell Progenitors. In Lymphokine Receptor Interactions 179: 229. INSERM/John Libbey Eurotext LTD, 1989.
Lee, G. et al. Normal B Cell Precursors Responsive to Recombinant Murine IL-7 and Inhibition of IL-7 Activity by Transforming Growth Factor-.beta.. J. Immunol. 142: 3875; 1989.
Takeda, S. et al. In Vitro Effects of Recombinant Interleukin-7 on Growth and Differentiation of Bone Marrow Pro-B and Pro-T-Lymphocyte Clones and Fetal Thymocyte Clones. Proc. Natl. Acad. Sci. (USA) 86: 1634; 1989.
Hayashi, S. et al. Stepwise Progression of B Lineage Differentiation Supported by Interleukin-7 and Other Stromal Cell Molecules. J. Exp. Med. 171: 1683; 1990.
Everson, M. P. et al. Synergism of Interleukin 7 with Thymocyte Growth Factors Interleukin 2, Interleukin 6 and Tumor Necrosis Factor .alpha. in the Induction of Thymocyte Proliferation. Cellular Immunol. 127: 470; 1990.
Conlon, P. J. et al. Murine Thymocytes Proliferate in Direct Response to Interleukin-7. Blood 74: 1368; 1989.
Morrissey, P. J. et al. Recombinant Interleukin 7, Pre-B Cell Growth Factor, has Costimulatory Activity on Purified Mature T Cells. J. Exp. Med. 169: 707; 1989.
Chazen, G. D. et al. Interleukin 7 is a T-Cell Growth Factor. Proc. Natl. Acad Sci. (USA) 86: 5923; 1989.
Chantry, D. et al. Interleukin 7 (Murine Per-B Cell Growth Factor/Lymphopoietin 1) Stimulates Thymocyte Growth: Regulation by Transforming Growth Factor Beta. Eur. J. Immunol. 19:783; 1989.
Watson, J. D. et al. Effect of IL-7 on the Growth of Fetal Thymocytes in Culture. J. Immunol. 143: 1215; 1989.
Okazaki, H. et al. IL-7 Promotes Thymocyte Proliferation and Maintains Immunocompetent Thymocytes Bearing .alpha..beta. or .gamma..delta. T-Cell Receptors in Vitro: Synergism with IL-2. J. Immunol. 143: 2917; 1989.
Londei, M. et al. Interleukin 2 is a Growth Factor for Mature Human T Cells. Eur. J. Immunol. 20:425; 1990.
Armitage, R. J. et al. Regulation of Human T Cell Proliferation by IL-7. J. Immunol. 144: 938; 1990.
Grabstein, K. H. et al. Regulation of T Cell Proliferation by IL-7. J. Immunol. 144: 3015; 1990.
Welch, P. A. et al. Human IL-7: A Novel T Cell Growth Factor. J. Immunol. 143: 3562; 1989.
Suda, T. et al. Growth Promoting Activity of IL-1a, IL-6, and Tumor Necrosis Factor-a in combination with IL-2, IL-4, or IL-7 on Murine Thymocytes. J. Immunol. 144: 3039; 1990.
Lynch, D. H. et al. IL-7 Induces LAK Activity in Resting Murine T Cells. Abstract, FASEB meeting, Jun. 4-7, 1990.
Henney, C. S. Interleukin 7: Effects on Early Events in Lymphopoiesis. Immunology Today 10: 170; 1989.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Adoptive immunotherapy with interleukin-7 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Adoptive immunotherapy with interleukin-7, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Adoptive immunotherapy with interleukin-7 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1758866

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.