Process for producing 2-carbon-substituted carbapenem derivative

Details Process for producing 2-carbon-substituted carbapenem derivative Process for producing 2-carbon-substituted carbapenem derivative

1992-12-11

1993-11-02

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48704

Patent

active

052585093

ABSTRACT:
A process for producing a 2-(unsubstituted or carbon-substituted)-1-carbapen-2-em-3-carboxylic acid derivative, which comprises reacting a 2-trifluoromethanesulfonyloxy-1-carbapen-2-em-3-carboxylic acid derivative or the 1-carbapen-2-em-3-carboxylic acid derivative derived from a 2-oxo-1-carbapenam-3-carboxylic acid derivative and trifluoromethanesulfonic anhydride, and a stannane derivative in an inert solvent in the presence of a palladium compound and a salt.

REFERENCES:
patent: 4895940 (1990-06-01), O'Neill et al.
patent: 5025006 (1991-06-01), DiNinno et al.
patent: 5025007 (1991-06-01), Greenlee et al.
patent: 5025008 (1991-06-01), DiNinno et al.
patent: 5037820 (1991-08-01), DiNinno et al.
Solomons, T. W. Graham, Organic Chemistry. N.Y., John Wiley & Sons, 1984, pp. 665-666.
March, Jerry, Advanced Organic Chemistry. N.Y., John Wiley & Sons, 1985, pp. 310-312 and 405-406.
Larock, Richard C. Comprehensive Organic Transformations. N.Y., VCH Publishers, Inc., 1989, p. 58.
Milstein et al. "Palladium-catalyzed . . . ", JACS, vol. 101 (17), 1979, pp. 4992-4998.
Sheffy et al. "palladium catalyzed crosscoupling . . . " JACS, vol. 105, 1983, pp. 7173-7175.
Stille, John K., "The Palladium-catalyzed cross-coupling Reactions . . . " Agnew. Chem. Int. Ed. Engl., vol. 25, 1986, pp. 508-524.
Journal of the American Chemical Society, vol. 108, No. 11, pp. 3033-3040, May 28, 1986, W. J. Scott, et al., "Palladium-Catalyzed Coupling of Vinyl Triflates with Organostannanes. Synthetic and Mechanistic Studies".

Affiliated with

Also associated with

Rating

Process for producing 2-carbon-substituted carbapenem derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for producing 2-carbon-substituted carbapenem derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for producing 2-carbon-substituted carbapenem derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1758771