Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...
Patent
1995-05-16
1999-05-18
Naff, David M.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
4241581, 424542, 435174, 435178, 435180, 436518, 436529, 436824, 514 2, 514 21, 5303871, 5303891, 530413, 530810, 530813, 530856, 530858, A61K39/395;38/55
Patent
active
059049227
ABSTRACT:
Antivenoms to snake, spider, scorpion and jelly fish venoms are produced for treatment of humans and animals, and for analytical use. Polyvalent antivenoms are produced containing immunoglobulin which is greater than fifty percent venom reactive. Purified polyvalent antivenom is derived from a first polyvalent antivenom having two or more monovalent subpopulations, and purified such that greater than fifty percent of the monovalent subpopulations are recovered by weight. The antivenoms can be horse or avian such as chicken antivenom. Chicken antivenom is obtained using a whole venom that is not glutaraldehyde pretreated, and the antivenom contains yolk immunoglobulin. Antivenoms are purified with an antigen matrix containing a single whole venom or a plurality of whole venoms covalently attached to an insoluble support such as aldehyde-activated agarose. Preferably, the whole venoms forming the plurality of whole venoms are selected from the four whole venoms of C. atrox, B. atrox, C. adamanteus and C. durissus terrificus. A combination of immobilized C. atrox and C. durissus terrificus whole venoms can substantially purify antivenom reactive with all four venoms. The antivenoms are intravenously injected to treat an envenomed mammalian subject.
REFERENCES:
patent: 3836433 (1974-09-01), Wirth et al.
patent: 4550019 (1985-10-01), Polson
patent: 5196193 (1993-03-01), Carroll
patent: 5340923 (1994-08-01), Carroll
Criley, B.R., Venoms, Buckley & Porges, eds., Am. Assoc. Advan. Sci., Washington, D.C. 1956, pp. 373-380.
Parrish, et al., Clinical Toxicology, 3(3), Sep. 1970, pp. 501-511.
Wingert and Wainschel, S. Med. J. 68:1015 (1975).
Christopher and Rodning, S. Med. J. 79:159 (1986).
Ellenhorn and Barceloux, In: Medical Toxicology (Elsevier Press) (1988) Ch. 39, pp. 1112-1132.
Parrish, Public Health Rpt. 81:269 (1966).
Russell et al., JAMA 233:341 (1975).
Ayeb and Delori, In: Handbook of Natural Toxins, vol. 2., Insect Poisons, Allergens, and Other Invertebrate Venoms (Anthony T. Tu, Ed.) (Marcel Dekker) (1984) Ch. 18, pp. 607-638.
Hassan, In: Handbook of Natural Toxins, vol. 2., Insect Poisons, Allergens, and Other Invertebrate Venoms (Anthony T. Tu, Ed.) (Marcel Dekker) (1984) Ch. 17, pp. 577-605.
Lumley et al., Med. J. Aust. 148:527 (1988).
Endean, Toxicon 25:483 (1987).
Olson et al., Toxicon 22:733 (1984).
Baxter and Marr, Toxicon 7:195 (1969).
Habermehl, In: Venomous Animals and Their Toxins, (Springer-Verlag, Berlin) (1981).
MacDonald et al., Am. J. Epidemiology 124:794 (1986).
Tacket et al., Am J. Med. 76:794 (1984).
Thorne and Gorbach, In: International Encylcopedia of Pharmacology and Therapeutics, Pharmacology of Bacterial Toxins (Dorner and Drews, Eds.) (Pergamon Press, Oxford) (1986), pp. 5-16.
Russell, JAMA, 215:1994 (1971).
Audibert et al., Proc. Natl. Acad. Sci. USA 79:5042 (1982).
Alouf, Ann. Inst. Pasteur/Microbiol. 136B:309 (1985).
New et al., New Eng. J. Med. 311:56 (1984).
Freitas et al., Toxicon 27:341 (1989).
Perez et al., Toxicon 22:967 (1984).
Iddon et al., Toxicon 26:167 (1988).
Martinez et al., Toxicon 27:239 (1989).
Russell et al., Toxicon 8:63 (1970).
Curry et al., J. Toxicol. Clin. Toxicol. 21:417 (1983-1984).
World Health Organization Publication No. 58, Geneva (1981).
Sutherland, Med. J. Aust. 1:613 (1977).
Christensen, In: Snake Venoms, (Springer-Verlag, Berlin) (1979) Ch. 20, pp. 825-846.
Parrish and Hayes, Clin. Tox. 3:501 (1970).
Yang et al., Toxicon 15:51 (1977).
Kukongviriyapan et al., J. Immunol. Meth. 49:97 (1982).
Karlsson et al., Eur. J. Biochem. 21:1 (1971).
Lomonte et al., Toxicon 23:807 (1985).
Sullivan et al., J. Vet Hum. Toxicol. 24:192 (Suppl.) (1982).
Sullivan and Russell, Proc. West. Pharmacol. Soc. 25:185 (1982).
Sullivan and Russell, Toxicon Suppl. 3:429 (1983).
Jeter et al., Toxicon 21:729 (1983).
Bar-Or et al., Clin. Tox. 22:1 (1984).
Russell et al., Am J. Trop. Med. Hyg. 34:141 (1985).
Sullivan, Ann. Emerg. Med. 16:938 (1987).
Johnstone and Thorpe, In: Immunochemistry in Practice, 2nd Edition (Blackwell Scientific Publications 1987) p. 209.
Polson et al., Immunol. Comm. 9:495 (1980).
Benson et al., J. Immunol. 87:616 (1961).
Benedict and Yamaga, In: Comparative Immunology, Immunoglobulins and Antibody Production in Avian Species (J.J. Marchaloni, Ed.) (Blackwell, Oxford) (1966) Ch. 13, pp. 335-375.
Patterson et al., J. Immunol. 89:272 (1962).
Carroll and Stollar, J. Biol. Chem. 258:24 (1983).
Philpot, Jr., et al., Toxicon 16:603 (1978).
Towbin et al., Proc. Nat. Acad. Sci. USA 76:4350 (1979).
Weber and Osborn, In: The Proteins, 3rd Edition (H. Neurath and R.L. Hill, Eds.) (Academic Press, NY) (1975) pp. 179-223.
Carroll and Laughon, In: DNA Cloning: A Practical Approach, vol. III (D. Glover, Ed.) (IRL Press, Oxford) (1987) pp. 89-111.
Theakston, In: Natural Toxins. Animal, Plant and Microbial (J.B. Harris, Ed.) (Clarenden Press, Oxford) (1986) pp. 287-303.
Ohsaka, In: Snake Venoms, Handbook of Experimental Pharmacology, vol. 52 (C.Y. Lee, Ed.) (Springer-Verlag, Berlin) (1979) pp. 480-546.
Martin et al., J. Biol. Chem. 262:4452 (1987).
Kabat, In: Structural Concepts in Immunology and Immunochemistry (Holt, Rhinehart, and Winston, NY) (1968) pp. 35-40.
Ownby et al., Toxicon 21:849 (1983).
B.S. Thalley and S.B. Carroll, Bio/Technology 8:934 (1990).
Mebs et al., Toxicon 26:453 (1988).
dos Santos et al., Toxicon 27:297 (1989).
Sterogene Biochemicals, Brochure, "Actisep .TM. Immunoaffinity Purification System".
Coulter et al., Med. J. Aust. 1:433 (1980).
Ho et al., Am. J. Trop. Med. Hyg. 35:579 (1986).
Ho et al., Toxicon 24:211 (1986).
Theakston and Reid, Toxicon 17:511 (1979).
Theakston, Toxicon 21:341 (1983).
Chandler and Hurrell, Clinica Chemica Acta 121:225 (1982).
Minton et al., Clin. Toxicol. 22:303 (1984).
Minton, Ann. Emerg. Med. 16:932 (1987).
Weinstein et al., Toxicon 23:825 (1985).
Schaeffer et al., Toxicon 26:67 (1988).
Naff David M.
Ophidian Pharmaceuticals Inc.
LandOfFree
Treatment with polyvalent antivenom containing immunoglobulin wh does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Treatment with polyvalent antivenom containing immunoglobulin wh, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Treatment with polyvalent antivenom containing immunoglobulin wh will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1758555