Methods and apparatus for analyzing electrophoresis gels

Details Methods and apparatus for analyzing electrophoresis gels Methods and apparatus for analyzing electrophoresis gels

1996-11-13

1999-05-18

Beisner, William H.

Chemistry: electrical and wave energy

Processes and products

Electrophoresis or electro-osmosis processes and electrolyte...

204612, 382129, G01N27/26

Patent

active

059048220

ABSTRACT:
This invention relates to a system and methods for the straightening an electrophoresis gel image in the vertical and horizontal directions, and for analyzing a straightened gel image. The system includes an input unit for receiving raw data from the electrophoresis gel, a straightening unit for providing a straightened gel image, an output unit for portraying the raw data from the electrophoresis gel and the straightened gel image, and a an analyzing unit for analyzing the data portrayed in the straightened gel image. The system features a dye boost feature for boosting the intensity of bands, filtering means for modifying the gel image, and a genotype editing feature for editing the results of an automatic gel analysis. The system allows for manual and automatic analysis of the straightened gel image according to a specified set of analysis parameters providing a range of analysis stringency levels.

REFERENCES:
patent: 5073963 (1991-12-01), Sammons et al.
patent: 5400249 (1995-03-01), Soll et al.
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CAPLUS abstract of McKenzie et al. ("Zone electrophoresis of .beta.-lactoglobulins", Nature(London), 1966, 212(5058), 161-3), 1966 Month Unavailable.
CAPLUS abstract of Metzker et al. (Accurate determination of DNA in agarose gels using the novel algorithm GelScann(1.0), Comput. Appl. Biosci. (1995), 11(2), 17-94), 1995 Month Unavailable.
CAPLUS abstract of Bala et al. ("2-DG induced modulation of chromosomal DNA profile, cell survival, mutagenesis and gene conversion in X-irradiated yeast", Indian J. Exp. Biol. (1996), 34(1), 18-26), Jan. 1996.
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