Phenyl alpha acyloxyalkanoic acids, derivatives and their therap

Details Phenyl alpha acyloxyalkanoic acids, derivatives and their therap Phenyl alpha acyloxyalkanoic acids, derivatives and their therap

1990-12-20

1993-11-02

Ore, Dale R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

424DIG5, 424 59, 424 60, 424 61, 424 62, 424 63, 424 64, 424 65, 424 69, 424 70, 514 29, 514169, 514533, 514725, 514844, 514845, 514846, 514847, 514852, 514859, 514860, 514861, 514863, 514864, 514873, 514880, 514881, 514886, 514887, 514928, 514944, 514969, A61K 7025, A61K 7035, A61K 706, A61K 740, A61K 748, A61K 906, A61K 3170, A61K 31215

Patent

active

052583910

ABSTRACT:
Therapeutic as well as preventative measures to improve the cosmetic conditions or to alleviate the symptoms of dermatologic disorders with phenyl alpha acyloxyalkanoic acids and derivatives is disclosed. The cosmetic conditions and dermatologic disorders in humans in which the compounds may be useful include brittle or soft nails; abnormally thin skin, mucous membranes or wound; friction blisters; brittle hairs; pruritus; acne; and diseased nails, skin or mucous membranes due to natural or unnatural causes including but not limited to in flammations or infections. The phenyl alpha acyloxyalkanoic acids and derivatives include, for example, diphenyl alpha acetoxyacetic acid, phenyl alpha acetoxyacetic acid, phenyl alpha methyl alpha acetoxyacetic acid and phenyl alpha acetoxypropanoic acid. The compositions containing the active ingredients are also useful for treatment of skin, nails and hair conditions or disorders in domestic animals.

REFERENCES:
patent: 3879537 (1975-04-01), Van Scott et al.
patent: 3920835 (1975-11-01), Van Scott et al.
patent: 4105783 (1978-08-01), Yu et al.
patent: 4216224 (1980-08-01), Yu et al.
patent: 4246261 (1981-01-01), Van Scott et al.
patent: 4363815 (1982-12-01), Yu et al.
patent: 4518789 (1985-05-01), Yu et al.
Merck Index, 1976, p. 1060; 7961.
Current Therapy, p. 662 (1981).
Current Therapy, pp. 599-603 (1984).
The Merck Index, 9th ed., abst 7961 (1976).

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