Cholera toxin gene regulated by growth hormone promoter

Details Cholera toxin gene regulated by growth hormone promoter Cholera toxin gene regulated by growth hormone promoter

1990-05-18

1993-06-29

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 692, 4351723, 4353201, C12N 1531

Patent

active

052236102

ABSTRACT:
The present invention contemplates a method of physiologic engineering by genetically altering second messenger levels in cells. This method allows the hyperactivation or inhibition of cell function within cells, tissues and animals by introducing a foreign gene that alters a second messenger system. The use of physiologically engineered animals as systems for determining the effectiveness of therapeutic compositions is also contemplated.

REFERENCES:
Behringer et al. (1988), Genes & Dev., vol. 2(4), pp. 453-461, (Chem. Abstracts, vol. 109, 180607).
Mekalanos et al., (Dec., 1983), Nature, vol. 306, pp. 551-557.
Palmiter et al., Cell, 50:435-443 (1988).
Brinster et al., Cell, 27:223-231 (1981).

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