New benzylcyclanone derivatives process for preparing them and c

Details New benzylcyclanone derivatives process for preparing them and c New benzylcyclanone derivatives process for preparing them and c

1990-03-29

1993-06-29

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514473, 549331, 549475, 549477, A61K 3134, C07D30794

Patent

active

052235335

ABSTRACT:
The invention relates to the benzylcyclanone derivatives of formula: ##STR1## where R.sub.1 and R.sub.3 denote H, OH, linear or branched C.sub.1 -C.sub.8 alkyl or linear or branched C.sub.1 -C.sub.8 alkoxy, R.sub.2 and R.sub.4 represent H or OH, at least one of the two being OH, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 represent H, C.sub.1 -C.sub.18 alkyl, aralkyl or aryl, it being possible for R.sub.5 and R.sub.6 and/or R.sub.7 and R.sub.8 to form an optionally substituted, saturated C.sub.5 -C.sub.12 ring, X represents O or --(CR.sub.9 R.sub.10).sub.n with n=1 or 2 and R.sub.9 and R.sub.10 represent H or CH.sub.3 ; if X represents --(CR.sub.9 R.sub.10).sub.n, R.sub.6 and R.sub.8, with the atoms of the ring to which they are attached, form a bicyclic system having 7 or 8 carbon atoms; if X represents --(CR.sub.9 R.sub.10).sub.n with n=1, R.sub.9 and R.sub.10 =CH.sub.3, R.sub.5 =H and R.sub.6 and R.sub.8, with the atoms of the ring to which are attached, form a bicyclic system having 7 carbon atoms, R.sub.7 can represent a --CH.sub.2 SO.sub.3 H residue, optionally in salt form.
Process for preparing these compounds and their use as antioxidants and medicinal products for the treatment of skin allergies and inflammations.

REFERENCES:
patent: 3717659 (1973-02-01), Sarett et al.
Yin, CA 61:4297b, 1964.
Katsumi et al., "Chem. Pharm. Bull.", 34(4), 1986, pp. 1619-1627.
Rainsford et al., "Anti-Inflammatory and Anti-Rheumatic Drugs", Vol. III, Chapter 4, CRC Press, Inc. 1985, pp. 105-121.
Chemical Abstracts, vol. 56, Abstract No. 8673g (1961).

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