Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-12-30
1993-06-29
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 31505
Patent
active
052235009
ABSTRACT:
A method for preparing d,1-5-methyltetrahydrofolic acid and the salts thereof of the formula: ##STR1## wherein X is hydrogen, an alkaline metal or alkaline earth metal; by reduction of folic acid with sodium borohydride followed by the methylation of the tetrahydrofolic acid thus obtained with aqueous solutions of formaldehye and sodium borohydride in an inert atmosphere.
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J. A. Blair and Saunders, "A Convenient Method for the Preparation of d,1-5-Methyltetrahydrofolic Acid (d,1-5-methyl-5,6,7,8,-tetrahydropteroly-L-monoglutamic acid)", Analytical Biochemistry, 34, 376-381 (1970).
Sakami, "Sodium 5-Methyltetrahydrofolate", Biochemical Preparations, No. 10 1963 pp. 103-106.
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Bioresearch S.p.A.
Daus Donald G.
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