Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-12-28
1993-06-29
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514212, 5142395, 514255, 514331, 514357, 514408, 514416, 514429, 540480, 540484, 540596, 540611, 544 582, 544 59, 544 60, 544129, 544132, 544141, 544159, 544165, 544166, 544359, 544395, 544402, 546208, 546231, 546332, 548482, 548518, 548577, 548578, 5483331, C07D295135, C07D20704, C07D, C07D, A61K 31435, A61K 31495, A61K 31535, A61K 31521
Patent
active
052234983
ABSTRACT:
Compounds of formula I ##STR1## and their salts in which n=0 or 1, R.sub.1 and R.sub.2 are each aliphatic or cycloalkyl or NR.sub.1 R.sub.2 is an optionally substituted heterocyclic ring, R.sub.3 is alkyl, cycloalkyl or optionally substituted amino, R.sub.5 is an aliphatic group, R.sub.6 is H, an optionally substituted aliphatic group or a cycloalkyl group, or R.sub.3 and R.sub.5 together with the nitrogen and carbon atoms to which they are attached form an optionally substituted heterocyclic ring or R.sub.5 and R.sub.6 together with the nitrogen to which they are attached form a heterocyclic ring optionally substituted by alkyl and R.sub.7 is optionally substituted alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkoxycarbonyl, trifluoromethyl or cyano have utility as hypoglycemic agents.
REFERENCES:
patent: 3300494 (1967-01-01), Cragoe
patent: 3320229 (1967-05-01), Szabo et al.
patent: 3399211 (1968-08-01), Sarett et al.
patent: 3468887 (1969-09-01), Stahle et al.
patent: 3479401 (1969-11-01), Patchett et al.
patent: 3479437 (1969-11-01), Szabo et al.
patent: 3487087 (1969-12-01), Sarett et al.
patent: 3622596 (1971-11-01), Fischer et al.
patent: 3636219 (1972-01-01), Culik et al.
patent: 3663610 (1972-05-01), Ecsery et al.
patent: 3769274 (1973-10-01), Wollweber et al.
patent: 3818070 (1974-06-01), Wollweber et al.
patent: 3855292 (1974-12-01), Wollweber et al.
patent: 3875230 (1975-04-01), Pissiotas
patent: 3897474 (1975-07-01), Pissiotas
patent: 3903302 (1975-09-01), Wollweber et al.
patent: 3911010 (1975-10-01), Wollweber et al.
patent: 3911013 (1975-10-01), Wollweber et al.
patent: 3911014 (1975-10-01), Wollweber et al.
patent: 3919315 (1975-11-01), Wollweber et al.
patent: 3923888 (1975-12-01), Wollweber et al.
patent: 3925470 (1975-12-01), Wollweber et al.
patent: 3925471 (1975-12-01), Wollweber et al.
patent: 3965176 (1976-06-01), Gold
patent: 3996247 (1976-12-01), Wollweber et al.
patent: 4013676 (1977-03-01), Wollweber et al.
patent: 4018814 (1977-04-01), Wollweber et al.
patent: 4182865 (1980-01-01), Rasmussen
patent: 4211867 (1980-07-01), Rasmussen
patent: 4250173 (1981-02-01), Cantello
patent: 4281004 (1981-07-01), Ives
patent: 4282356 (1981-08-01), Cantello
patent: 4287201 (1981-09-01), Olson et al.
patent: 4340609 (1982-07-01), Chou
patent: 4342764 (1982-08-01), Ilvespaa et al.
patent: 4348406 (1982-09-01), Nafissi-Varchei
patent: 4414211 (1983-11-01), Rasmussen
patent: 4436921 (1984-03-01), Hori et al.
patent: 4448963 (1984-05-01), Hori et al.
patent: 4450170 (1984-05-01), Beeley et al.
patent: 4460774 (1984-07-01), Hori et al.
patent: 4477664 (1984-10-01), Hori et al.
patent: 4477666 (1984-10-01), Hori et al.
patent: 4533739 (1985-08-01), Pitzele et al.
patent: 4539400 (1985-09-01), Fabre et al.
patent: 4546100 (1985-10-01), Fabre et al.
patent: 4558063 (1985-12-01), Beeley et al.
patent: 4560690 (1985-12-01), Reiter
patent: 4584297 (1986-04-01), Fabre et al.
patent: 4596818 (1986-06-01), Newsome et al.
patent: 4619931 (1986-10-01), Heeres et al.
patent: 4626537 (1986-12-01), Dave et al.
patent: 4656270 (1987-04-01), Maryanoff et al.
patent: 4665085 (1987-05-01), Coquelet et al.
patent: 4666915 (1987-05-01), Ozeki et al.
patent: 4693850 (1987-09-01), Maryanoff et al.
patent: 4701447 (1987-10-01), Vashi et al.
patent: 4723029 (1988-02-01), Vashi et al.
patent: 4735942 (1988-04-01), Heeres et al.
patent: 4735959 (1988-04-01), Grell et al.
patent: 4861879 (1989-08-01), Heeres et al.
Wollweber et al, Chem. Abstract vol. 76, No. 72265g (1971).
Wollweber et al., Chem. Abstract vol. 76, No. 72395z (1971).
Derwent Abstract 06230A/01 of German Patent Specification 2626128.
Derwent Abstract 87-057419/09 of German Patent Specification 3529692.
Abstract 73 of the 190th ACS National meeting held Sep. 8-12, 1985 in Chicago.
Pfeiffer and Sazrazin, Bio. Chem. Hoppe Seyler 366 311 (1985) titled "Metabolic Effects of Ring-Substituted Arylalkylguanidines on Insulin-Sensitive Systems, I. Amino-Substituted Benzylguanidines".
Derwent Abstract 84-257488/42 of German Patent Specification 3312516.
Derwent Abstract 85-126127/21 of Japanese Patent Application 85/64964.
Drug Data Report 1986, p. 376 pub. May 1986 contains a further abstract of Japanese Patent Appln. 85/64964.
Chemical Abstract 92 76401b, Nardi et al. (1979).
Chemical Abstract 69 52140q, (1967), Instituto Farmacologico Experimental.
Derwent Abstract 83059W/50 of U.S. Pat. No. 3,922,282.
Chemical Abstracts 50 14002b (1956), Synerholm.
Chemical Abstracts 53 8125 (1956), Cavallini.
Kessler et al., "Tetrahedran" 26 1805-1820 (1970).
Leffek et al., Can. J. Chem. 67 590-595 (1989).
Hughes et al., J. Med. Chem. 18 1077-1088 (1975).
Matsuo et al., Chem. Pharm. Bull 33 4409-4421 (1985).
Derwent Abstract 66-36253F of Dutch Patent Appln 68.11711.
Datlow Philip
Shah Mukund J.
The Boots Company PLC
LandOfFree
Phenylamidine and phenylguanidine derivatives and their use as a does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Phenylamidine and phenylguanidine derivatives and their use as a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenylamidine and phenylguanidine derivatives and their use as a will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1755516