Novel arginine, glycine, aspartic acid derivatives as platelet-a

Details Novel arginine, glycine, aspartic acid derivatives as platelet-a Novel arginine, glycine, aspartic acid derivatives as platelet-a

1989-12-01

1991-10-01

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530330, 530331, 548953, A61K 3700

Patent

active

050533924

ABSTRACT:
Disclosed are novel amino acid derivatives of the formula: ##STR1## wherein X is H, amidino or ##STR2## Y is H, amino or ##STR3## Z is ##STR4## OR.sub.1 or a naturally occurring L-amino acid, bounded to the carbon atom at the .alpha.-amino position;

REFERENCES:
patent: 4683291 (1987-07-01), Zimmerman et al.
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Haverstick et al., "Inhibition of Platelet Adhesion to Fibronectin, Fibrinogen, and vWF Substrates by a Synthetic Tetrapeptide Derived From the Cell-Binding Domain of Fibronectin"; Blood, vol. 66, No. 4 (Oct.), 1985: pp. 946-952.
Plow et al., "Inhibition of Fibrinogen Binding to Human Platelets by the Tetrapeptide glycyl-L-prolyl-L-arginyl-L-proline"; Proc. Natl. Acad. Sci. U.S.A., vol. 79, pp. 3711-3715, Jun. 1982.
Plow et al., "The Effect of Arg-Gly-Asp-Containing Peptides on Fibrinogen and von Willebrand Factor Binding to Platelets"; Proc. Natl. Acad. Sci. U.S.A., vol. 82, pp. 8057-8061, Dec. 1985.
Santoro et al. ; "Competition for Related but Nonidentical Binding Sites on the Glycoprotein IIb-IIIa Complex by Peptides Derived from Platelet Adhesive Proteins"; Cell, vol. 48, 867-873, Mar. 13, 1987.
Ruggeri et al.; "Inhibition of Platelet Function with Synthetic Peptides Designed to be High-Affinity Antagonists of Fibrinogen Binding to Platelets"; Proc. Natl. Acad. Sci. U.S.A.; vol. 83, pp. 5708-5712, Aug. 1986.
Ruoslahti et al. ; "Arg-Gly-Asp: A Versatile Cell Recognition Signal", Cell, vol. 44, 517-518, Feb. 28, 1986.

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