Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1989-09-29
1992-06-16
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530858, 514 21, 424537, 424538, C07K 1508, C07K 302, A61K 3702
Patent
active
051225964
ABSTRACT:
This invention relates to a polypeptide found to be present in the venom of the Agelenopsis aperta spider and to polypeptides having substantially the same amino acid sequence and substantially the same activity as said polypeptide. The polypeptides of this invention and the salts thereof block calcium channels in cells of various organisms and are useful in blocking said calcium channels in cells, per se; in the treatment of calcium channel mediated diseases and conditions; and in the control of invertebrate pests. This invention also relates to compositions comprising said polypeptides and salts thereof.
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Phillips Douglas
Saccomano Nicholas A.
Volkmann Robert A.
Lumb J. Trevor
McFarlin D. Stuart
Pfizer Inc.
Richardson Peter C.
Walsh Stephen
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