Method for the mass growth of cells in a thin film of nutrient m

Details Method for the mass growth of cells in a thin film of nutrient m Method for the mass growth of cells in a thin film of nutrient m

1990-11-09

1993-06-29

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352402, 43524023, 43524024, 435285, 435286, 435287, 435313, 435812, C12N 500, C12N 502, C12N 999, A23L 1202

Patent

active

052234290

ABSTRACT:
A method for the mass growth of cells (2) which consists in growing the cells (2) in a thin film, e.g. a bubble or foam, of nutrient medium (4), which is continuously recirculated to the bulk medium (1) for replenishing. Growth rate and yields obtained with this method in large scale cell culturing are far superior to those obtained by know methods, due to the increased metabolic exchange of the cells (2) with the environment.

REFERENCES:
patent: 3717551 (1973-02-01), Bizzini et al.
patent: 3948725 (1976-04-01), Irie
patent: 4144126 (1979-03-01), Burbidge
patent: 4224413 (1980-09-01), Burbidge
Large Scale Cell Culture Technology (1987) Edited by Bjorn K. Lydersen, pp. 69-70, Macmillan (U.S.A.) and Collier Macmillan (Canada) Publishing Company.

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