Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1991-05-03
1993-06-29
Rosen, Sam
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436501, 436506, 436509, 436510, 436518, C12Q 100
Patent
active
052233960
ABSTRACT:
A method for the detection of the presence of inflammation in a patient by measuring the amount of circulating intercellular adhesion molecule (cICAM-1) in a sample of one or more bodily fluids of the patient and then comparing the amount of cICAM-1 in the sample to standards normal for the bodily fluid or fluids assayed. The amount of cICAM-1 can be measured using anti-ICAM-1 antibodies. Higher than normal amounts of cICAM-1 indicate the presence of inflammation. Also contemplated is a method for the detection of organ transplant or tissue graft rejection.
REFERENCES:
Marlin et al. Nature vol. 344 (Mar. 1990) pp. 70-72.
Dustin et al, The Journal of Immunology vol. 137, No. 1 (Jul. 1, 1986) pp. 245, 246 & 252-254.
Marlin Steven D.
Rothlein Robert
Boehringer Ingelheim Pharmaceuticals Inc.
Frankhouser David E.
Reitenbach Daniel
Rosen Sam
Timbers Mary-Ellen M.
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