Process for the optical resolution of (+)-2-hydroxy-4-phenylbuta

Details Process for the optical resolution of (+)-2-hydroxy-4-phenylbuta Process for the optical resolution of (+)-2-hydroxy-4-phenylbuta

1989-02-09

1990-02-27

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562470, C07B 5500

Patent

active

049048228

ABSTRACT:
A process for the optical resolution of (.+-.)-2-hydroxy-4-phenylbutanoic acid which comprises treating (.+-.)-2-hydroxy-4-phenylbutanoic acid with an optically active 1-(p-tolyl)ethylamine or an optically active N-(2-hydroxy)ethyl-.alpha.-methylbenzylamine as a resolving agent is provided by the present invention.
According to the invention, (-)-2-hydroxy-4-phenylbutanoic acid, which is useful as a starting substance for the synthesis of angiotensin converting enzyme-inhibiting pharmaceuticals, can especially be obtained in a highly pure state and in a high yield.

REFERENCES:
patent: 3725437 (1973-04-01), Nagoya et al.
patent: 3867434 (1975-02-01), Diamond
Chemical Abstracts, vol. 109, No. 3, Jul. 18, 1988, Columbus, Ohio, U.S.A., M. Hashimoto "Preparation of Arylhydroxyalkanoic Acid Derivatives as Intermediates for Pharmaceuticals", p. 584, col. 2, abstract No. 22 654n & Jpn. Kodai tokkyo Koho JP 62, 212 329.

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