Transverse forced gas cooling for capillary zone electrophoresis

Chemistry: electrical and wave energy – Apparatus – Coating – forming or etching by sputtering

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2041801, G01N 2726, B01D 5702

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active

051222531

ABSTRACT:
An apparatus for capillary zone electrophoresis having a selectively removable capillary cassette, the internal walls of which define a toroidal capillary region and a gas flow path therethrough. Within the capillary region is housed a helically wound capillary tube having an inlet end and an outlet end. An electrical field is applied across the ends of the tube to cause electrophoretic separation of molecules of a sample. A stream of pressurized gas, preferably air, is channeled through the capillary region for cooling of the tube. The gas flow is a transverse flow and is channeled to avoid differentiation in cooling capacity. The transverse cross-sectional area of the gas flow path is substantially uniform throughout to prevent change in flow velocity. The gas flow path is a generally U-shaped path having a smooth radius turn. In progressing through the capillary region, the stream of gas is caused to flow at an angle relative to the axis of the helix, thereby promoting thermal isolation of succeeding loops of the helically wound capillary tube.

REFERENCES:
patent: 4612106 (1986-09-01), Kromer et al.
patent: 4705616 (1987-11-01), Andresen et al.
patent: 4708782 (1987-11-01), Andresen et al.
patent: 4842701 (1989-06-01), Smith et al.
patent: 5037523 (1991-08-01), Weinberger et al.

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