Intracorporeal iontophoretic method

Details Intracorporeal iontophoretic method Intracorporeal iontophoretic method

1991-09-25

1993-06-29

Pellegrino, Stephen C.

Surgery

Means for introducing or removing material from body for...

Infrared, visible light, ultraviolet, x-ray or electrical...

604 49, 604 21, A61N 130

Patent

active

052229360

ABSTRACT:
A method of intracorporeal iontophoretic treatment of an internal hollow body organ containing a physiological ion-rich fluid environment by delivery to said hollow body organ of drug ions by means of an iontophoretic device inserted into said hollow body organ and comprising an active electrode which has the same polarity as the drug ions to be delivered. The method comprises direct measurement of the pH of said physiological fluid environment, whereby indirectly measuring its ionic composition and selecting accordingly the material of said active electrode so that it either can interact with ions contained in said physiological environment or allow the interaction of said environmental ions with water hydrolysis products so as to reduce the ionic species competitive with said drug ions during the iontophoretic process.

REFERENCES:
patent: 4744787 (1988-05-01), Phipps et al.
patent: 4747819 (1988-05-01), Phipps et al.
patent: 4752285 (1988-06-01), Petelenz et al.
patent: 4915685 (1990-04-01), Petelenz et al.
patent: 5057072 (1991-10-01), Phipps

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