Protein thrombolytic agent with absorption enhancing agent

Details Protein thrombolytic agent with absorption enhancing agent Protein thrombolytic agent with absorption enhancing agent

1985-10-01

1988-09-20

Rosen, Sam

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 7, 514 8, 514579, 514588, 514646, 514659, 514663, 424166, 424101, A61K 3700

Patent

active

047725850

ABSTRACT:
The absorption rate of protein-thrombolytic agents with medicinal properties in the blood is enhanced by administering the protein intramuscularly together with an absorption enhancing agent, e.g. hydroxylamine or a salt thereof.

REFERENCES:
patent: 4153689 (1979-05-01), Hirai
patent: 4658830 (1987-04-01), Sarnoff
patent: 4661469 (1987-04-01), Sarnoff
Ar-is Sobel et al. Proceeding with Proc. and Natl. Acad. Sci. USA, vol. 82, pp. 4258-4262, Jun. 1985.
AS is Hills et al., Abstract of the 58th Scientific Session Circulation Oct. 1984; 72(4):III-69.
AT is Fox et al., F.A.C.C., vol. 7, No. 2, Feb. 1986.
Nasal Absorption of Insulin Dogs, Diabetes, vol. 27, No. 3, pp. 296-299.
Nasal Administration of Insulin in Patients with Diabetes Medica International Congress Series, 1979, pp. 319-326.
Insulin Given Intranasally Induces Hypoglycaemia in Normal and Diabetic Subjects, British Medical Journal, vol. 284, Jan. 30, 1982, pp. 303-306.
Insulin Administered Intranasally as an Insulin-Bile Sale Aerosil, Diabetes, vol. 32, Nov. 1983, pp. 1040-1047.
Intranasal Aerosolized Insulin, The New England Journal of Medicine, Apr. 25, 1985, pp. 1078-1084.

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