Inhibitor of C5a-mediated chemotaxis

Details Inhibitor of C5a-mediated chemotaxis Inhibitor of C5a-mediated chemotaxis

1986-05-23

1988-09-20

Brown, J. R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530825, 435 69, 436 86, 436 89, A61K 3702

Patent

active

047725842

ABSTRACT:
Polypeptides are disclosed which inhibit the binding of the C5a chemotaxin to polymorphonuclear leukocytes by cleaving a six amino acid peptide from the carboxy-terminus of the C5a chemotaxin. The polypeptides can be isolated from virulent strains of group A streptococci, s. pyogenes, by enzymatic or detergent extraction.

REFERENCES:
patent: 3929994 (1975-12-01), Hirsch et al.
Wexler et al., Proc. Natl. Acad Sci., USA, 82, pp. 8144-8148 (Dec. 1985).
P. A. Ward et al., J. Immunology, 111, 1771 (1973).
K. J. Johnson et al., J. Clin. Invest., 59, 951 (1977).
P. A. Ward et al., J. Clin. Invest., 58, 123 (1976).
D. E. Wexler et al., Infection and Immunity, 39, 239 (1983).
P. P. Cleary et al., Recent Advances in Streptococci and Steptococcal Diseases, Y. Kinura et al., eds., Reed Books, Ltd., England (Jul. 1, 1985) at pp. 179-180.

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