Derivatives of novobiocin

Details Derivatives of novobiocin Derivatives of novobiocin

1978-02-15

1979-04-03

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

542417, 542439, 542441, 195 80R, 536 13, 424281, 424180, C07D31156

Patent

active

041477049

ABSTRACT:
The present invention relates to processes for the chemical oxidation of novobiocin-type compounds (I) to their corresponding hydroxy derivative (II) or aldehyde (III) and formation of novobiocin derivatives from these oxidation products. The oxidation products and derivatives have antibacterial activity.

REFERENCES:
patent: 2966484 (1960-12-01), Walton
patent: 2966509 (1960-12-01), Stammer
patent: 3049534 (1962-08-01), Wallick
patent: 3049551 (1962-08-01), Walton
patent: 3175944 (1965-03-01), Hoeksema
patent: 3652536 (1972-03-01), Sebek et al.
patent: 3890297 (1975-06-01), Dolak

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