Triazoloquinazolines

Details Triazoloquinazolines Triazoloquinazolines

1975-02-25

1977-01-11

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602564F, 2602564Q, C07D48704

Patent

active

040027554

ABSTRACT:
Triazoloquinazolines of the formula, ##STR1## wherein R.sub.1 is C.sub.1.sub.-4 alkyl or aryl; R.sub.2 and R.sub.3 are independently hydrogen, halogen, trifluoromethyl, nitro, C.sub.1.sub.-4 alkyl or C.sub.1.sub.-4 alkoxy, or R.sub.2 and R.sub.3 together may form methylenedioxy; and R.sub.4 is hydrogen, C.sub.1.sub.-4 alkyl, aralkyl, C.sub.1.sub.-4 haloalkyl, or C.sub.3.sub.-6 cycloalkyl; and pharmaceutically acceptable acid addition salts thereof are prepared by (a) reacting a 2-hydrazinoquinazoline derivative with a carboxylic acid or reactive derivative thereof, (b) cyclizing a 2-acylhydrazinoquinazoline derivative with heating or (c) reacting a triazolylbenzophenone derivative with ammonia. Said triazoloquinazolines and pharmaceutically acceptable acid addition salts thereof show excellent anti-inflammatory and analgesic activities.

REFERENCES:
patent: 3313815 (1967-04-01), Wolfe et al.
patent: 3838126 (1974-09-01), Wagner
Young et al., "Arch. Int. Pharmacodyn", vol. 212, 1974, pp. 205-213.
Naqui et al., "Tetrahedron Letters", No. 25, 1962, pp. 1193-1198.

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