Mitomycin phosphate derivatives

Details Mitomycin phosphate derivatives Mitomycin phosphate derivatives

1988-06-29

1989-10-17

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548415, 548422, 514421, C07D48714, A61K 3140

Patent

active

048747793

ABSTRACT:
Disclosed herein are N.sup.7 -alkylphosphate derivatives of mitomycin C and porfiromycin showing antitumor activity against transplanted human tumor and reduced toxicity relative to the parent N.sup.7 -alkanol mitomycin compounds.

REFERENCES:
patent: 4185111 (1980-01-01), Ducep et al.
patent: 4642352 (1987-02-01), Kaneko et al.
Iyengar et al, J. Med. Chem., 1981, 24:975-981 and J. Med. Chem., 1983, 26:16-20.
Sinkula & Yalkowsky, J. Pharm. Sci., 1975, 64:181-210 at 189-191. Japan Kokai 21-95, 394 and 21-95, 393, Derwent Abst. No. 87-281016 and 87-281015.

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