Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1987-09-15
1989-10-17
Rosen, Same
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 6, 424 941, A61K 3702
Patent
active
048747424
ABSTRACT:
A composition and a method of making a whole blood substitute are disclosed. The claimed invention duplicates the two phase heterogeneous physico-chemical system of natural whole blood and accordingly, is capable of carrying out virtually all of the physiological functions of whole blood. Albumin dispersed in a solution composed of distilled water, sodium chloride and urea, and to which a surface active agent such as lecithin is subsequently added, constitutes the preferred method of preparing the two phase aqueous liquid system on which this invention is based. Other ingredients necessary to the manufacture of the claimed composition of matter include stroma free hemoglobin, an appropriate sterol, electrolytes and proteins. Emulsification of the two phase aqueous liquid system and the additives given immediately above completes the preparation of the claimed synthetic whole blood.
The method of manufacture described in this disclosure also provides for the separation of the phases of the two phase aqueous liquid system. Separation of the coacervate phase aqueous liquid system. Separation of the coacervate phase from the external equilibrium phase may be carried out prior to the introduction of the additives referred to above. In the preferred procedure, separation takes place after emulsification has been completed.
Introduction of the claimed synthetic whole blood into the circulation is accomplished through intravenous transfusion. When introduced into the circulation, the coacervate phase of this invention will serve the functions of normally occuring hematocrit.
REFERENCES:
patent: 4343797 (1982-08-01), Ecanow et al.
patent: 4439424 (1984-03-01), Ecanow et al.
patent: 4539204 (1985-09-01), Ecanow et al.
patent: 4547490 (1985-10-01), Ecanow et al.
patent: 4558032 (1985-12-01), Ecanow et al.
patent: 4596788 (1986-06-01), Ecanow et al.
Ecanow Bernard
Ecanow Charles S.
Rosen Same
Synthetic Blood Corporation
LandOfFree
Synthetic whole blood and a process for preparing the same does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthetic whole blood and a process for preparing the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthetic whole blood and a process for preparing the same will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1743604