Thieno[2,3-O]azepine compounds and CNS affecting use thereof

Details Thieno[2,3-O]azepine compounds and CNS affecting use thereof Thieno[2,3-O]azepine compounds and CNS affecting use thereof

1989-01-06

1990-02-27

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540594, C07D49504, A61K 3138

Patent

active

049046535

ABSTRACT:
Compounds of the formula ##STR1## in which R.sup.1 is hydrogen, hydroxy, nitro, cyano, halo, amino, acetamido, hydroxy-C.sub.1-4 alkyl, carboxaldehydo, C.sub.1-4 alkylcarbonyl, carboxy, C.sub.1-4 alkoxy-carbonyl, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphonyl or C.sub.1-4 alkoxy-C.sub.1-4 alkyl, R.sup.2 is hydrogen, hydroxy, nitro, cyano, halo, amino, carboxamido, acetamido, hydroxy-C.sub.1-4 alkyl, carboxyaldehydo, C.sub.1-4 alkylcarbonyl, carboxy, C.sub.1-4 alkoxycarbonyl, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphonyl, C.sub.1-4 alkoxy-C.sub.1-4 alkyl, oximino or aminomethyl, R.sup.3 is optionally substituted phenyl or optionally substituted phenyl ortho condensed with an optionally substituted ring selected from benzene, cyclohexane, cyclohexene, cyclopentane or cyclopentene, in which ring one of the carbon atoms may be replaced by oxygen, sulphur or nitrogen, and R.sup.4 is hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl or optionally substituted benzyl; and salts thereof; have central nervous system activity.

REFERENCES:
patent: 4414225 (1983-11-01), Sauter et al.
patent: 4575504 (1986-03-01), Sauter et al.
patent: 4751222 (1988-06-01), Brasstrup et al.
A Barnett, Drugs of the Future, II, 49-56 (1986).
Andersen et al., Eur. J. Pharmacol., 137, 291-92 (1987).
Aldrich Chemical Company, Inc., Catalog, Milwaukee, WI, 1988, p. 1430.
Reagents for Organic Synthesis, Louis F. Fieser and Mary Fieser, John Wiley and Sons, Inc., 1967, p. 314.

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