Process for the preparation of 1-[L-(-)-.gamma.-amino-.alpha.-hy

Details Process for the preparation of 1-[L-(-)-.gamma.-amino-.alpha.-hy Process for the preparation of 1-[L-(-)-.gamma.-amino-.alpha.-hy

1974-05-23

1976-08-10

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

260210AB, 536 17, A61K 3171, C07H 1522

Patent

active

039741370

ABSTRACT:
1-[L-(-)-.gamma.-amino-.alpha.-hydroxybutyryl]-kanamycin A is a compound useful as an antibacterial agent. A new process for its preparation has been developed which comprises using aldehyde blocking agents on the amine functions prior to acylation with L-(-)-.gamma.-amino-.alpha.-hydroxybutyric acid.

REFERENCES:
patent: 3781268 (1973-12-01), Kawaguchi et al.
patent: 3792037 (1974-02-01), Kawaguchi et al.
patent: 3796699 (1974-03-01), Naito et al.
patent: 3832286 (1974-08-01), Weinstein et al.
patent: 3852264 (1974-12-01), Weinstein et al.
patent: 3868360 (1975-02-01), Daniels et al.

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