Process for preparing gamma-dimethylamino L-beta hydroxy butyric

Details Process for preparing gamma-dimethylamino L-beta hydroxy butyric Process for preparing gamma-dimethylamino L-beta hydroxy butyric

1985-06-28

1986-07-15

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560170, 564136, 564197, C07C10130

Patent

active

046007946

ABSTRACT:
Gamma dimethylamino L-beta hydroxy butyric acid (L-norcarnitine) is prepared by reacting gamma-iodo beta hydroxy butyric acid octyl ester with dimethylamine in a lower alkanol, e.g. ethanol, thereby obtaining a mixture of the hydroiodides of the gamma-dimethylamino L-beta hydroxy butyric acid ethyl ester and dimethylamide (in a molar ratio of about 60:40). The mixture is eluted on a weakly basic ion exchange resin activated in the OH.sup.- form in order to remove the iodide ions. Upon subsequent alkaline hydrolysis the desired compound is obtained.

REFERENCES:
patent: 3223700 (1965-12-01), Klauehn
Keller, J. Med. Chem., 6 pp. 202-203 (1963).
Stokke, Biochim. Biophys Acta, 218 pp. 552-554 (1970).

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