Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-03-20
1986-07-15
Henderson, Christopher A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546229, 546230, 548342, 549492, 514927, C07D27720, C07D21118
Patent
active
046007806
ABSTRACT:
New N-cyano-formamidine are disclosed of the formula I: ##STR1## wherein R is 2-[[(5-methyl-1H-Imidazol-4-yl)methyl]thio]ethyl, 2-[[[5-[dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl, 2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl or 3-[3-(1-piperidinylmethyl)phenoxy]propyl, as well as a process for its production, and pharmaceutical preparations containing the same. The compounds possess histamine--induced gastric acid secretion--inhibiting activity, and are indicated for use in the treatment of peptic ulcer and other pathologies caused or stimulated by gastric acidity.
REFERENCES:
patent: 4252819 (1981-02-01), Hirata
patent: 4309433 (1982-01-01), Hirai
Receptors Mediating Some Actions of Histamine by A. S. F. Ash and H. O. Schild, pp. 427-439, (1966).
N-cyanoimidates by K. R. Huffmann and F. C. Schaffer, (1963).
Definition and Antagonism of Histamine H.sub.2 -Receptors by J. W. Black, et al.
Anglada Luis
Castello Jose M.
Foguet Rafael
Ortiz José A.
Raga Manuel M.
Ferrer International, S.A.
Henderson Christopher A.
Striker Michael J.
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