Pharmacologically active tricyclic quinazolinones

Details Pharmacologically active tricyclic quinazolinones Pharmacologically active tricyclic quinazolinones

1975-02-26

1976-07-13

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424244, A61K 31505

Patent

active

039695069

ABSTRACT:
The compounds are biologically active tricyclic quinazolinones of the class of imidazo[2,1-b]quinazolin-5-ones, pyrimido[2,1-b]quinazolin-6-ones and diazepino[2,1-b]quinazolin-7-ones, useful, for example, as bronchodilator agents. Processes for preparation of said compounds include the reaction of a N-carboxy anthranilic anhydride (an isatoic anhydride) with a cyclic pseudothiourea such as 2-organomercapto-4,5-dihydroimidazole or 2-organomercapto-3,4,5,6-tetrahydropyrimidine.

REFERENCES:
patent: 3296447 (1967-01-01), Papesch
patent: 3468888 (1969-09-01), Chow
patent: 3598823 (1971-08-01), Hardtmann

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