2-[2-hydroxy-4-(substituted)phenyl]piperidines

Details 2-[2-hydroxy-4-(substituted)phenyl]piperidines 2-[2-hydroxy-4-(substituted)phenyl]piperidines

1983-03-14

1985-07-16

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546221, 546216, 546187, 546188, 546194, 546208, 546226, 546232, 546233, 546235, 546237, 546238, 546240, 514867, A61K 31445, C07D21146

Patent

active

045297320

ABSTRACT:
2-[2-Hydroxy-4-(substituted)phenyl]piperidines and derivatives thereof of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R.sub.1 is H, benzyl or certain acyl groups, R.sub.2 is H, certain alkyl, alkenyl, alkynyl, hydroxyalkyl, acyl or alkylsulfonyl groups; R.sub.3 is H.sub.2, O, ##STR2## and Z is (C.sub.1 -C.sub.13)alkylene or -(alk.sub.1).sub.m -O-(alk.sub.2).sub.n - where each of (alk.sub.1) and (alk.sub.2) is (C.sub.1 -C.sub.13)alkylene, provided that the number of carbon atoms in (alk.sub.1) plus (alk.sub.2) is not greater than 13; each of m and n is 0 or 1; and W is H, pyridyl or optionally substituted phenyl; their use as analgesic agents, intermediates therefor and processes for their preparation.

REFERENCES:
patent: 2498431 (1950-02-01), Lee
patent: 4147872 (1979-04-01), Althuis et al.
patent: 4216218 (1980-08-01), Klioze et al.
patent: 4306097 (1981-12-01), Harbert et al.

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