Modified crosslinked stroma-free tetrameric hemoglobin

Details Modified crosslinked stroma-free tetrameric hemoglobin Modified crosslinked stroma-free tetrameric hemoglobin

1983-05-04

1985-07-16

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

260112B, 260112R, 260112SR, 424101, A61K 3700, A61K 3514, A23J 106, C07G 700

Patent

active

045297193

ABSTRACT:
Stroma-free deoxy mammalian tetrameric hemoglobin is crosslinked with certain bis diaspirin esters and modified with pyridoxyl-5'-phosphate followed by reduction to produce bis-diamide covalently crosslinked, pyridoxal-5'-phosphate covalently modified tetrameric hemoglobin wherein the crosslinking and modifying bonds occur in the beta cleft. The modified crosslinked stroma-free tetrameric hemoglobin of this invention is a disease-free, oxygen transporting discrete molecular species, free from cell surface antigens, having use as a substitute for transfusion of red blood cells. This modified crosslinked stroma-free hemoglobin is a stable oxygen carrying protein capable of oxygen delivery to perfused tissue and advantageously remaining in the intravascular space.

REFERENCES:
Tye, Ross W., Prog. Clin. Biol. Res. Apr. 1983, vol. 122, pp. 41-49 "Modification of Hemoglobin-Tetrameric Stabilization".
Walder et al., Biochemistry, vol. 18, No. 20, 1979, pp. 4265-4270, "Diaspirins that Crosslink .beta. Chains & Hemoglobin . . . ".
Greenburg et al., Surgery vol. 36 (1) pp. 13-16 1979, "Intravascular Persistence and Oxygen Delivery . . . ".
Walder, Joseph et al., J. Mol. Biol. vol. 141, pp. 195-216 1980, "Development of Antisickling Compounds . . . Binding Site".

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