Preparation of trifluoromethyltoluene from halomethylbenzotriflu

Details Preparation of trifluoromethyltoluene from halomethylbenzotriflu Preparation of trifluoromethyltoluene from halomethylbenzotriflu

1988-05-12

1989-07-18

Evans, J. E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Halogen containing

570144, C07C 1724, C07C 1738, C07C 2124, C07C 1700

Patent

active

048495573

ABSTRACT:
Trifluoromethyltoluene is obtained from a halomethylbenzotrifluoride, which is a relatively inexpensive material, by hydrogenating the halomethyl group of the starting compound to methyl group with hydrogen gas in the presence of a hydrogenation catalyst and an acid acceptor. Suitable examples of the halomethyl group to be hydrogenated are --CH.sub.2 Cl, --CH.sub.2 F, --CHClF, --CClF.sub.2 and --CF.sub.3. When the starting compound is bis(trifluromethyl)benzene, addition of either an alcohol or an alkali metal fluoride to the reaction system is effective for suppression of formation of xylene as a by-product, and xylene still contained in the reaction product can completely be removed by treatment with a sulfonating agent such as fuming sulfuric acid.

REFERENCES:
patent: 3381041 (1968-04-01), Kometumi et al.
patent: 4558166 (1985-12-01), Baasner et al.

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