Production of angiogenetic factor

Details Production of angiogenetic factor Production of angiogenetic factor

Filed on

1982-12-27

Date issued

1985-07-16

Examiner

Chan, Nicky

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Whole live micro-organism, cell, or virus containing

SubSubClass

Genetically modified micro-organism, cell, or virus

Other Related Categories

424 85, A61K 3512, A61K 3900

Type

Patent

Status

active

Patent number

045295905

Description

ABSTRACT:
A process for the production of tumor angiogenetic factor and the production of antigens from a purified angiogenetic factor is shown in the present invention. The production of tumor angiogenetic factor is accomplished by injecting a material of a suitable composition to initiate production of fluid in the cavity of a living animal by inciting an inflammatory response in the cavity tissues, which response is characterized by the production of granulation tissue comprised mostly of new capillaries. After the body cavity is partly filled with the exudate, the fluid is tapped out of the cavity and purified to yield angiogenetic factor. The production of antigens is accomplished by dissolving the purified angiogenetic factor in an equal volume of distilled water, reacting the dissolved angiogenetic factor in the distilled water with a gluteraldehyde solution for at least twelve (12) hours and lyophilizing resulting mixture for storage. Animals injected with the product produce antibodies which react with the purified angiogenetic factor.

REFERENCES:
patent: 4229532 (1980-10-01), Tolbert et al.
Brown et al., "Angiogenic Factor from Synovial Fluid . . . ", The Lancet, Mar. 29, 1980, pp. 682-685.
Ackerman et al., "Three Day Pleural Inflammation . . . ", in Chem. Abstracts, vol. 93, 1980, 231000m.
Hartveit et al., "Serum Complement Levels . . . ", in Chem. Abstracts, vol. 79, 1973, 1045m.

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