Cephalosporin derivatives

Details Cephalosporin derivatives Cephalosporin derivatives

1982-08-16

1985-03-05

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 22, 544 26, 544 27, C07D50114, A61K 31545

Patent

active

045032203

ABSTRACT:
3-Vinylcephalosporin derivatives of the formula: ##STR1## in which the symbols R.sub.1 are phenyl radicals or radicals --OZ.sub.1 (it being possible for Z.sub.1 to be alkyl, 2,2,2-trichloroethyl or optionally substituted phenyl or benzyl, or for the radicals Z.sub.1 to form an alkylene radical), R.sub.2 is a radical which can be removed by an enzymatic method, or a protecting radical, and R.sub.3 and R.sub.4 are optionally substituted alkyl, or phenyl, or together form a saturated 5-membered or 6-membered heterocyclic ring optionally containing another hetero-atom, are new, crystallizable intermediates useful for the preparation of anti-bacterial cephalosporins.

REFERENCES:
patent: 3998817 (1976-12-01), Fukumura et al.
patent: 4043991 (1977-08-01), Hamma et al.
patent: 4067866 (1978-01-01), Foglio et al.
patent: 4145540 (1979-03-01), Ochiai et al.
patent: 4307233 (1981-12-01), Farge et al.
patent: 4316016 (1982-02-01), Walker et al.
patent: 4365062 (1982-12-01), Farge et al.

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