Spiro-linked pyrrolidine-2,5-diones active as enzyme aldose redu

Details Spiro-linked pyrrolidine-2,5-diones active as enzyme aldose redu Spiro-linked pyrrolidine-2,5-diones active as enzyme aldose redu

1982-05-11

1985-03-05

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 8, 546 10, 546 18, 546 65, 546 81, 546153, 546165, 548302, 548404, 548410, 548411, 549 23, 549 24, 549 26, 549 27, 549 28, 549387, 549390, 549391, 549407, 549433, A61K 3141, C07D491107

Patent

active

045030669

ABSTRACT:
The invention provides various medical compositions for use in treating or preventing certain of the side effects of diabetes or galactosemia. The active ingredients are selected from a series of novel aldose reductase inhibitory spiro-linked pyrrolidine-2,5-diones of the general formula: ##STR1## or a pharmaceutically acceptable salt, or a non-toxic, biodegradable precursor thereof. Processes for the production of these compounds are also provided. A particular compound suitable for use as an active ingredient is spiro[pyrrolidine-3,9'-xanthene]-2,5-dione.

REFERENCES:
patent: 3185696 (1965-05-01), Tien
patent: 3652558 (1972-03-01), Lundsford et al.
patent: 4117230 (1978-09-01), Sarges
patent: 4307108 (1981-12-01), Belletire et al.
Rice, et al., "Chemical Abstracts", vol. 74, 1971, col. 125384n.
Brittain, et al., "Chemical Abstracts", vol. 98, 1983, col. 98:143291e.
J. Heterocyclic Chemistry, 1971, 8, 155-156.
J. Medicinal Chemistry, 1981, 24, 47-53.

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