Substituted 3-cyclobutene-1,2-diones, pharmaceutical composition

Details Substituted 3-cyclobutene-1,2-diones, pharmaceutical composition Substituted 3-cyclobutene-1,2-diones, pharmaceutical composition

1983-06-13

1985-03-05

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 60, 544124, 544147, 544364, 544379, 546194, 546213, 546214, 546256, 546283, 546281, 546272, 546275, 548517, 514216, 514222, 514230, 514232, 514237, 514252, 514318, 514326, 514332, 514357, 514422, 514438, 514445, 514471, 514579, 549492, 549495, 549444, C07D41714, C07D41314, C07D41914, A61K 3134, A61K 3155, A61K 31535, C07D30746

Patent

active

045030510

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.12 is a leaving group, Z is S, O or CH.sub.2 and A is a phenyl, furyl, thienyl or pyridyl ring substituted by a ##STR2## moiety, in which R.sup.8 and R.sup.9 are various substituents or, when taken together with the nitrogen, may be a specified heterocyclic ring, are intermediates in the preparation of histamine H.sub.2 -antagonist anti-ulcer agents of the formula ##STR3## in which R.sup.1 and R.sup.2 are any of several specified substituents.

REFERENCES:
patent: 4233302 (1980-11-01), Martin-Smith et al.

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