Phosphinylcycloalkylcarbonyl and phosphinylcycloalkenylcarbonyl

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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548112, C07D20700

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active

048495255

ABSTRACT:
Compounds of the formula ##STR1## and their pharmaceutically acceptable salts wherein Z completes a cycloalkyl ring, a substituted cycloalkyl ring, a cycloalkenyl ring, a substituted cycloalkenyl ring or a saturated heteroalkyl ring; R.sub.2 is lower alkyl, aralkyl or aminoalkyl and X is an amino or imino acid. The compounds possess angiotensin converting enzyme inhibition activity.

REFERENCES:
patent: 4374131 (1983-02-01), Petrillo, Jr.
patent: 4381287 (1983-04-01), Karanewsky et al.
patent: 4384123 (1983-05-01), Petrillo, Jr.
patent: 4432971 (1984-02-01), Karanewsky et al.
patent: 4468519 (1984-08-01), Krapcho
patent: 4499079 (1985-02-01), Weller et al.
patent: 4560506 (1985-12-01), Weller et al.
patent: 4560681 (1985-12-01), Karanewsky
Weller et al., Biochemical and Biophysical Research Communications; Design of Conformationally Constrained Angiotensin-Converting Enzyme Inhibitors, Nov. 30, 1984, vol. 125, pp. 82-89.

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