Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-09-21
1989-07-18
Lee, Mary C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548112, C07D20700
Patent
active
048495255
ABSTRACT:
Compounds of the formula ##STR1## and their pharmaceutically acceptable salts wherein Z completes a cycloalkyl ring, a substituted cycloalkyl ring, a cycloalkenyl ring, a substituted cycloalkenyl ring or a saturated heteroalkyl ring; R.sub.2 is lower alkyl, aralkyl or aminoalkyl and X is an amino or imino acid. The compounds possess angiotensin converting enzyme inhibition activity.
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Weller et al., Biochemical and Biophysical Research Communications; Design of Conformationally Constrained Angiotensin-Converting Enzyme Inhibitors, Nov. 30, 1984, vol. 125, pp. 82-89.
Gordon Eric M.
Weller, III Harold N.
Barrack Donald J.
E. R. Squibb & Sons Inc.
Lee Mary C.
Magrab E. Brendan
Venetianer Stephen
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