Deoxyribonucleoside phosphoramidites in which an aliphatic amino

Details Deoxyribonucleoside phosphoramidites in which an aliphatic amino Deoxyribonucleoside phosphoramidites in which an aliphatic amino

1986-06-24

1989-07-18

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 1910, C07H 1920

Patent

active

048495131

ABSTRACT:
The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

REFERENCES:
patent: 4668777 (1987-05-01), Caruthers
Fourrey et al., Chemical Abstracts, vol. 104, 1986, 130215a.
Tanaka et al., Chemical Abstracts, vol. 106, 1987, 33420x.

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