Process for the preparation of 7.alpha.-methoxy-7.beta.-(1,3-die

Details Process for the preparation of 7.alpha.-methoxy-7.beta.-(1,3-die Process for the preparation of 7.alpha.-methoxy-7.beta.-(1,3-die

1980-11-19

1983-09-13

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 544 27, C07D50157, A61K 3154

Patent

active

044043732

ABSTRACT:
The invention relates to novel 7.alpha.-methoxycephalosporin derivatives having at the 7.beta.-position an amido group acylated by a 1,3-dithietane carboxylic acid residue and to 7.beta.-isothiazolylthioacetamido-7.alpha.-methoxycephalosporins having antibacterial activity by themselves and, as the case may be, capable of being converted into the aforesaid 7.alpha.-methoxycephalosporin derivatives. The compounds of this invention exhibit excellent antibacterial activity and are particularly effective against gram negative bacteria.

REFERENCES:
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patent: 4007176 (1977-02-01), Berger et al.
patent: 4008246 (1977-02-01), Ochiai et al.
patent: 4198339 (1980-04-01), Iwanami et al.
patent: 4203899 (1980-05-01), Ochiai et al.
patent: 4263432 (1981-04-01), Iwanami et al.
patent: 4299829 (1981-11-01), Kamiya et al.
patent: 41828680 (1980-01-01), Ochiai et al.

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