Method of using alkenyl- or alkynyl-substituted thiobarbiturates

Details Method of using alkenyl- or alkynyl-substituted thiobarbiturates Method of using alkenyl- or alkynyl-substituted thiobarbiturates

1987-04-09

1989-05-23

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3119

Patent

active

048331481

ABSTRACT:
Methods and compositions are described for treatment to control brain damage associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of an alkenyl-substituted or alkynyl-substituted thiobarbiturate characterized in having broad-spectrum activity as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites.

REFERENCES:
patent: 3930006 (1975-12-01), Wiggins et al.
Merck Index p. 1207 9th Ed. (1976).

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