Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-10-23
1989-05-23
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
5142255, 5142258, 5142252, A61K 3154
Patent
active
048331384
ABSTRACT:
Compounds, compositions and methods of treatment are described to control brain damage associated with anoxia or ischemia which typically follows such conditions as stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a phenothiazinealkaneamine compound as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrido; wherein each of R.sup.3 and R.sup.4 is independently selected from hydrido, methyl and ethyl; wherein each of R.sup.5 and R.sup.6 is independently selected from methyl, ethyl and n-propyl; wherein X is sulfur; wherein m is zero; and wherein n is two.
REFERENCES:
Gordon, Psychopharmacological Agents, vol. II (1967), pp. 3-30.
Friedman Stanley J.
Keane J. Timothy
Matakaitis Paul D.
Washington University
LandOfFree
Phenothiazinealkaneamines for treatment of neurotoxic injury does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Phenothiazinealkaneamines for treatment of neurotoxic injury, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenothiazinealkaneamines for treatment of neurotoxic injury will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1730947