Method for the production of substituted or unsubstituted chloro

Details Method for the production of substituted or unsubstituted chloro Method for the production of substituted or unsubstituted chloro

1993-03-30

1994-02-22

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Halogen containing

570124, 570137, C07C 1716

Patent

active

052889327

ABSTRACT:
The present invention relates to a method for the production of substituted or unsubstituted chloromethyl and bromomethyl cyclopropane having a degree of purity above 85%, particularly above 90%, by reacting a hydroxymethyl cyclopropane of the formula ##STR1## where R is H, or one or two R groups are alkyl of from 1 to 10 carbon atoms or phenyl, with methane sulfonic acid chloride or methane sulfonic acid bromide in the presence of a trialkylamine and, if necessary, an organic solvent, preferably an organic solvent containing oxygen, at a temperature of from -20.degree. C. to +30.degree. C. over a period of time of from 1 to 30 hours, then heating the reaction mixture to a temperature of from 40.degree. to 80.degree. C., or to reflux temperature, without isolating the intermediate mesylate.

REFERENCES:
patent: 2950328 (1960-08-01), Orchin
patent: 2967181 (1961-01-01), Herrick et al.
patent: 4012430 (1977-03-01), Verbrugg et al.

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