Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1987-08-13
1989-05-23
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424449, A61F 1302
Patent
active
048329533
ABSTRACT:
A method for preventing the formation of crystalline hydrates in a dispersion of a hydratable liquid in a nonaqueous matrix is disclosed. The method is particularly useful in the manufacture of laminated items formed from such dispersions and comprises forming individual subunits from such dispersions, heating the subunits, preferably after they have been packed in sealed containers, to a temperature high enough to melt the crystalline hydrate, maintaining said subunits at such temperature for a time sufficient to melt all the crystalline hydrate present and to prevent the occurrence of crystals for an extended period of time after cooling and cooling subunits to ambient conditions. The use of the method in the manufacture of transdermal delivery devices for the delivery of scopolamine base is described.
REFERENCES:
patent: 4262003 (1981-04-01), Urquhart et al.
patent: 4436741 (1984-03-01), Urquhart et al.
patent: 4532244 (1985-07-01), Innes
patent: 4610875 (1986-09-01), Panoz et al.
Campbell Patricia S.
Enscore David J.
Gale Robert M.
Kaufman Arnold
ALZA Corporation
Mandell Edward L.
Page Thurman K.
Sabatine Paul L.
Stone Steven F.
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