Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic a

Details Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic a Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic a

1981-05-14

1983-09-13

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544239, C07D23714, C07D23704, C07D23724, A61K 3150

Patent

active

044042035

ABSTRACT:
Substituted 6-phenyl-3(2H)-pyridazinone compounds are useful as cardiotonic agents.
Said compounds cause a significant increase in myocardial contractility in the anesthetized dog. Said compounds are produced by reacting substituted benzoylpropionic acids with suitably substituted hydrazines to provide 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are dehydrogenated to the desired product.
The intermediate 6-phenyl-4,5-dihydro-3(2H)-pyridazinones are themselves useful as cardiotonic agents.

REFERENCES:
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17446 D/11 Derwent Abstract of Belgian Pat. No. 884,859, also enclosed.
Haginiwa, et al., Yakugaki Zasshi, 98, 67-71, (1978).
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Abstract of Ger. Pat. No. DT 2445-681.
William Curran et al., J. Med. Chem., 17, 273 (1974).
Luis Pitarch et al., Eur. Med. Chem. Chimica Therapeutica No. 6, 644 (1974).
Abstract of U.S. Pat. No. 4152-517.
Abstract of Japanese Pat. No. J51043-776.
Abstract of European Pat. No. EP 8391.
Abstract of European Pat. No. EP 10156.

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