Pyrazolo [3,4-b][1,5]benzodiazepine compounds

Details Pyrazolo [3,4-b][1,5]benzodiazepine compounds Pyrazolo [3,4-b][1,5]benzodiazepine compounds

1980-10-02

1983-09-13

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602456, 2602433, 424250, 548376, 548377, 544140, A61K 3155, C07D48704

Patent

active

044041373

ABSTRACT:
Compounds are described of the formula ##STR1## or an acid addition salt thereof; in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl C.sub.1-4 alkyl, halogen, C.sub.1-4 haloalkyl, C.sub.1-4 alkanoyl, nitro, amino, C.sub.2-4 acylamino, cyano, hydroxyl, C.sub.1-4 alkoxy, C.sub.1-4 alkylthio, C.sub.1-4 haloalkoxy or a group of the formula --SO.sub.2 N(R.sup.8).sub.2, --SO.sub.2 R.sup.8 or --SO.sub.3 R.sup.8 where R.sup.8 is C.sub.1-4 alkyl, C.sub.1-4 haloalkyl or optionally substituted phenyl; in which R.sup.5 is a group of the formula ##STR2## where R.sup.9 is hydrogen, C.sub.1-4 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, C.sub.2-4 alkenyl, C.sub.1-4 alkanoyl, benzyl, cyano or optionally substituted phenyl, where R.sup.10 is hydrogen, C.sub.1-4 alkyl or optionally substituted phenyl and where n is 0 or 1; in which R.sup.6 is hydrogen, C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl C.sub.1-4 alkyl, C.sub.1-4 haloalkyl, benzyl, C.sub.1-6 alkanoyl, C.sub.1-4 carbalkoxy or benzoyl; and in which R.sup.7 is one of the values of R.sup.6 or halogen, nitro, cyano, amino or C.sub.1-4 acylamino. The compounds are active as pharmaceuticals and particularly in the treatment of disorders of the central nervous system. Intermediate compounds in which R.sup.5 is thiol, hydroxy, or amino are also described.

REFERENCES:
patent: 3450694 (1969-06-01), Swett et al.
patent: 3660380 (1972-05-01), Schmidt et al.
patent: 3743734 (1973-07-01), Schmidt et al.
patent: 3758479 (1973-10-01), Schmutz et al.
patent: 3761481 (1973-10-01), Nakanishi et al.
patent: 3951981 (1976-04-01), Safir
patent: 3953430 (1976-04-01), Safir
patent: 4115568 (1978-09-01), Chakrabarti et al.
patent: 4115574 (1978-09-01), Chakrabarti et al.
patent: 4172831 (1979-10-01), Chakrabarti et al.
patent: 4317823 (1982-03-01), Rainer et al.
Plescia et al., Chem. Abstracts, vol. 92, Abstract No. 6514s, (1980).
Rajappa et al., Indian J. Chem., 1976, 14B, 394-396.
Rajappa et al., CA 85:177301e, (1976).
Schneider et al., CA 80:14969m, (1974).

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